Summer School 2019: Experimental Models for Neurodegenerative Disease: From Cells to Model Organisms.
2nd-5th July 2019 - Lille - France
SUMMER SCHOOL OVERVIEW
The objectives of the LiCEND Summer School are to present a large selection of experimental models and technological applications dedicated to the investigation of neurodegenerative diseases.
The LiCEND Summer School 2019 is based on the expertise of the Lille neuroscientists’ teams as well as highly-skilled international and French specialists. Gathering of such experts allows to propose an attractive and innovative training to the (future) researchers on neurodenegerative diseases.
Objectives: to present a large selection of experimental models and technological applications dedicated to the investigation of neurodegenerative diseases.
Currently, different experimental models are used to study the neurodegenerative mechanisms and associated processes, such as normal ageing, and to investigate a large variety of parameters: genetic and environmental factors, impact of metabolism, interaction with the immune system, cellular and molecular mechanisms, molecular screening, evaluation of therapeutic strategies… It is crucial to keep this in mind and to choose accordingly for each research project, which model(s) would be the most appropriate to fulfill the needs but also to know their limits (scientific relevancy, available tools and technologies, costs…)
The LiCEND Summer School 2019 “Experimental approaches to study neurodegenerative disorders in biology: from the cell dish to the model organisms” aims to provide students and professionals, a global view of experimental models of neurodegeneration with their respective “pro” and “cons” aspects.
To be open to an international audience, the training course will be in English.
Each session will be organized around one type of experimental models with 2 to 4 talks given by recognized specialists. The 3R rules have been considered while building those sessions, presenting alternative models to replace animals or allowing researcher to refine their experimentation by choosing the most efficient models to explore neurodegenerative diseases.
- Cellular models;
- Invertebrae models (C. Elegans, drosophia);
- Zebrafish model;
- Small mammals models (mouse and rat);
- Large mammals models.
More transversal sessions will also be proposed:
- The opening session will overview the current research issues and topics on neurodegenerative diseases;
- A closure session following the Large mammals models session and introducing the researches done on neurodegeneration in Wild animals;
- One session on animal research ethics and the way to present to the general audience, the use of animal models in research. Indeed, in the current context where the public opinion is really versatile on the topic of animal experimentation and where information available are mostly negatively biased, it is crucial to fully understand the stakes to explain clearly the use of animal and animal-derived experimental models for high quality researches on neurodegenerative diseases.
- One conference open to the general audience on the transfer of research from the lab bench to the patient bedside through the example of drug development.
The LiCEND Summer School has been thought in a way allowing attendees to be actors of the training course: some personal works will be asked to the PhD students before the training course (abstract and poster or flash talk sessions). Masser students and researchers outside the field of Neurosciences will be proposed to read some few review papers to prepare the summer school .
The LiCEND Summer School 2019 is targeted toward:
- Biomedical and Biology students with a Master 1 level minimum;
- Veterinary school students;
- Research and health professionals wishing for complementary training,
- Researchers outside the field of neurosciences but working in collaboration with neuroscientists.
Total number of attendees: 60
Summer school program
Tuesday 2nd of July 2019
Florence Pasquier, head of the Centre of Excellence in Neurodegeneration LiCEND (Memory Center, Neurology department, Lille University Hospital)
Opening session – Clinicians and researchers: what we are looking for?
- Neurodegenerative diseases: the clinicians’ unsolved issues.
Vincent Deramecourt (Memory Center, Neurology department, Lille University Hospital, France) LINK
- Mutations associated with early-onset Alzheimer’s disease: clinical, statistical and functional analysis
Anne Rovelet-Lecrux (University of Rouen Normandie, France)
- Can the gut be the missing piece in uncovering PD pathogenesis?
Pascal Derkinderen (Neurology department, Nantes Hospital, France)
- Experimental models to understand the contribution of neuroinflammation in Amyotrophic Lateral Sclerosis (ALS)
Séverine Boillée (ICM Institut du Cerveau et de la Moelle Epinière – INSERM U1127, CNRS UMR-7225; Sorbonne University, France) LINK
Wednesday 3rd of July 2019
- 5 flash talks
How to study neurodegenerative pathologies in a dish?
This session will focuse on Innovative cell models to replace live animals to study neurodegenerative diseases.
- Parkinson’s in a dish: Using stem cell-derived neurons to study molecular mechanisms and target discovery
Richard Wade-Martins (Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, UK) LINK
- Microfluidic neuron culture devices to study neural development and disease.
Devrim Kilinc (INSERM U1167 – Univ Lille – Institut Pasteur de Lille, France) LINK
- Functional characterization of neuronal networks using microelectrode array technology.
Sophie Halliez (Jean Pierre Aubert Research Center, Inserm, University of Lille, Lille University Hospital, France) LINK
- New tools to study APP metabolism (High Content Screening, optogenetic).
Julien Chapuis (INSERM U1167 – Univ Lille – Institut Pasteur de Lille, France)
LUNCH BREAK & POSTER SESSION
Rodents still matter
The animal sessions (rodent, apes, fish, big animals) aim to allow researcher to better “refine” their experimentations, presenting the current state of knowledge and helping to choose the most adequat models and protocols to test their hypotheses.
- Mouse models of tauopathy and their relevance to human disease
Diane Hanger (Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King’s College London, London, UK) LINK
- Prion-like diseases modelisation in murine model.
Morvane Colin (Jean Pierre Aubert Research Center, Inserm, University of Lille, Lille University Hospital, France) LINK
- Translational behavioral assessment in rodent models
Julie Deguil (UMR1171 – Inserm –University of Lille – Lille University Hospital, France)
- Brain administration, stereotaxis and pharmacological development with the animal models
David Devos (UMR1171 – Inserm –University of Lille – Lille University Hospital, France)
Thursday 4th of July 2019
- 5 flash talks
Planet of the Apes
- Philippe Hantraye (Molecular Imaging Research Center, Institut de biologie François Jacob, CEA Paris-Saclay, France)
- Studying pathophysiology of Parkinson Disease in non-human primates
Erwan Bézard (Institut des Maladies Neurodégénératives – Université de Bordeaux – CNRS UMR 5293, France)
Session on animal research ethics
- Transparency & Communication in Laboratory Animal Sciences – Challenges and Opportunities
Kirk Leech (European Animal Research Association, London, UK)
LUNCH & POSTER SESSION
Fishing for molecular mechanisms and new therapies
- Models for motor neuron diseases: Focus in zebrafish
Edor Kabashi (ICM Institut du Cerveau et de la Moelle Epinière, Paris, France) LINK
- Deciphering adverse outcome pathways of neurotoxic compounds in zebrafish
Demetrio Raldúa (Department Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain)
Conference open to the general public (venue to be defined)
- From the lab bench to the patient bedside: development of new drug treatments
Régis Bordet (UMR1171 – Inserm –University of Lille – Lille University Hospital, France))
Friday 5th of July 2019
Contributions from the invertebrate side
- Elegans: a not so simple model organism
Marie Gendrel (IBENS – CNRS UMR 8197 – INSERM U1024, Ecole Normale Supérieure – PSL, France)
- FUSsing with worms: insights into physiological and pathological protein condensates
Peter St George-Hyslop (Cambridge Institute for Medical Research, University of Cambridge, UK)
- The Drosophila organism model
Pierre Dourlen(INSERM U1167 – Univ Lille – Institut Pasteur de Lille, France)
- Drosophila as a model system to study genetics of Tau and TDP-43 proteinopathies
Bart Dermaut (Ghent University – Center for Medical Genetics, Ghent, Belgium)
- An evolutionarily conserved predictor of impending death: lessons from Drosophila melanogaster
Michael Rera CNRS, UMR8256, Institut de Biologie Paris-Seine, Sorbonne-Université, France)
LUNCH & POSTER SESSION
Animal farm. A fairy Story
- Prion in blood and its detection
Olivier Andreoletti (UMR1225 INRA-ENVT, Toulouse, France)
Closing session – Into the wild
- Chronic Wasting Disease in cervids
Sylvie Benestad (Norwegian Veterinary Institute, Oslo and Trondheim, Norway)
LiCEND Summer school fee
Application before 30/04/2019:
- Students, academic researchers, health professionals, veterinary researchers: 200 € VAT not included*
- Researchers and professionals from private sector: 500 € VAT not included*
(*: French VAT is 20%)
Application after 30/04/2019:
- Students, academic researchers, health professionals, veterinary researchers: 300 € VAT not included*
- Researchers and professionals from private sector: 600 € VAT not included*
(*: French VAT is 20%)
The fee includes coffee breaks for the Summer school duration and lunches on the 03, 04 and 05 July 2019.
Application and registration process
To apply to the Summer School, please fulfill the application form and submit your CV and covering letter. Once your application is validated, the administrative registration will take place.
Deadline for application: 23/06/2019
Deadline for administrative registration: 30/06/2019
Be warned that the registration fee is increased for application after the 30/04/2019
The number of registration is limited to 60 attendees: the first to apply will be the first to be selected.
Personal work and training credits
A preparatory work will be proposed to M1 and M2 students as well as non-biologists researchers: to read some review papers.
PhD students will have to submit an abstract and a poster. A flashtalk will be proposed to the best abstracts. Researchers can also propose an abstract and a poster.
For PhD students, the Summer School could eventually be integrated within their cursus: For the PhD studenst of the Lille Biology-Health Graduate school, 10 training credits will be attributed and 2 more credits if a flashtalk is performed.
For researchers working in France, the Summer school will also count as 12 hours of continuous training on animal experimentation.
The LiCEND Summer School will take place in the:
Faculté de Médecine de Lille – “Pole Formation”
2 Avenue Eugène Avinée, 59120 Loos, France
You can reach the faculty by walking 10 minutes from the “CHU-Eurasanté” terminus station on the Lille Line 1 subway
Coming to Lille
- Dr Sophie Halliez, Lille University, Alzheimer & Tauopathies team, JPArc – UMR-S-1172, pedagogic coordinator;
- Pr Kathy Dujardin, Neuropsychologist-Lille University Hospital, “Training” coordinator for the FHU VASCOG and LiCEND Centers of Excellence;
- Dr Maximilien Vanleene, LiCEND – FHU VasCog projects manager;
- Ms Charlotte Caillot, LiCEND – FHU VasCog projects attachée;